BML-277 (Chk2 Inhibitor II) chemical structure

BML-277 (Chk2 Inhibitor II)

Vendor: Selleckchem

Type: Cell Cycle

SKU: S8632-5mg

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BML-277 (Chk2 Inhibitor II) chemical structure

BML-277 (Chk2 Inhibitor II)

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Cell Cycle
Cas number
516480-79-8
Formula
C20H14ClN3O2
Small target
Chk
Smiles
C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
Storage conditions
2 years -80 in solvent
Scientific background
BML-277 (Chk2 Inhibitor II) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.
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