Inavolisib (GDC-0077)

Name: Inavolisib (GDC-0077)
Brand: Selleckchem
Price: 353.0 USD
Availability: InStock

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: S8668-5mg

$353.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

PI3K/Akt/mTOR

Cas number

2060571-02-8

Formula

C18H19F2N5O4

Small target

PI3K

Smiles

CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F

Storage conditions

3 years -20°C powder

Synonyms

RG6114, RO-7113755

Background

Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.

Inavolisib (GDC-0077)

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Product Overview

Background

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