Tolinapant (ASTX660)

Name: Tolinapant (ASTX660)
Brand: Selleckchem
Price: 163.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Apoptosis

SKU: S8681-1mg

$163.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Apoptosis

Cas number

1799328-86-1

Formula

C30H42FN5O3

Small target

IAP

Smiles

CC1CN(C(CN1)CN2CCOCC2C)CC(=O)N3CC(C4=C3C=C(C(=N4)CO)CC5=CC=C(C=C5)F)(C)C

Storage conditions

3 years -20°C powder

Background

Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.

Tolinapant (ASTX660)

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Product Overview

Background

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