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Atuveciclib (BAY-1143572) chemical structure

Atuveciclib (BAY-1143572)

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THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Cell Cycle
Cas number
1414943-88-6
Formula
C18H18FN5O2S
Small target
CDK
Smiles
COC1=C(C=CC(=C1)F)C2=NC(=NC=N2)NC3=CC=CC(=C3)CS(=N)(=O)C
Storage conditions
3 years -20°C powder
Scientific background
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
Technical documents

Documents

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