Enitociclib (BAY 1251152)

Name: Enitociclib (BAY 1251152)
Brand: Selleckchem
Price: 170.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S8730-5mg

$170.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

1610358-56-9

Formula

C19H18F2N4O2S

Small target

CDK

Smiles

COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)CS(=N)(=O)C

Storage conditions

3 years -20°C powder

Synonyms

(+)-BAY-1251152

Background

Enitociclib (BAY 1251152) is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.

Enitociclib (BAY 1251152)

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Product Overview

Background

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