Ripretinib chemical structure

Ripretinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8757-5mg

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Ripretinib chemical structure

Ripretinib

$170.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1442472-39-0
Formula
C24H21BrFN5O2
Small target
c-Kit
Smiles
CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
Storage conditions
3 years -20°C powder
Synonyms
DCC-2618
Scientific background
Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.
Technical documents

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