VU661013 chemical structure

VU661013

Vendor: Selleckchem

Type: Apoptosis

SKU: S8758-5mg

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For research use only — not intended for clinical or diagnostic purposes.
VU661013 chemical structure

VU661013

$428.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Apoptosis
Cas number
2131184-57-9
Formula
C39H39Cl2N5O4
Small target
Bcl-2
Smiles
CC1CN(C(=O)C2=C(C3=C(N12)C(=C(C=C3)Cl)C4=C(N(N=C4C)C)C)CCCOC5=CC(=C(C(=C5)C)Cl)C)C6=CN(C7=C6C=C(C=C7)C(=O)O)C
Storage conditions
3 years -20°C powder
Scientific background
VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
Technical documents

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