TAS0728 chemical structure

TAS0728

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8833-5mg

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For research use only — not intended for clinical or diagnostic purposes.
TAS0728 chemical structure

TAS0728

$269.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Protein Tyrosine Kinase
Cas number
2088323-16-2
Formula
C26H32N8O3
Small target
HER2
Smiles
CC1=C(C=CC(=C1C)NC(=O)C2=NN(C3=NC=NC(=C23)N)C4CCCN(C4)C(=O)C=C)CC(=O)N(C)C
Storage conditions
3 years -20°C powder
Synonyms
TPC 107
Scientific background
TAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent-binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4.9 nM, 8.5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity.
Technical documents

Documents

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