MYCi361 chemical structure

MYCi361

Vendor: Selleckchem

Type: Apoptosis

SKU: S8905-5mg

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$278.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
MYCi361 chemical structure

MYCi361

$278.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Apoptosis
Cas number
2289690-31-7
Formula
C26H16ClF9N2O2
Small target
Myc
Smiles
CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)O
Storage conditions
3 years -20°C powder
Synonyms
NUCC-0196361
Scientific background
MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
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