Tuxobertinib (BDTX-189) chemical structure

Tuxobertinib (BDTX-189)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S9786-5mg

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Tuxobertinib (BDTX-189) chemical structure

Tuxobertinib (BDTX-189)

$119.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
2414572-47-5
Formula
C29H29ClN6O4
Small target
EGFR
Smiles
ClC1=C(OCC2=NC=CC=C2)C=CC(=C1)NC3=NC=NC4=C3C=C(NC(=O)C=C)C(=C4)OCCN5CCOCC5
Storage conditions
3 years -20°C powder
Scientific background
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
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