Sitravatinib

Vendor: Abmole

Type: Molecular

SKU: M9626

$103.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Sitravatinib (MGCD516) is an orally active receptor tyrosine kinase (RTK) inhibitor. Inhibition of Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, and TRKB at 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, respectively. 29 nM, 5 nM and 9 nM. Sitravatinib alone has a potent antitumor effect and enhances pD-1 blockade activity by promoting the antitumor immune microenvironment.
Casnumber
1123837-84-2
Formula
C33H29F2N5O4S
Mw
629.68
Psmiles
COCCNCC1=CC=C(N=C1)C2=CC3=C(S2)C(=CC=N3)OC4=CC=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4F
Purity
100.0%
Solubility
DMSO ≥ 26 mg/mL
Target synonyms
MGCD516; MG516
Sitravatinib

Sitravatinib

$103.50 USD