Smad1 (phospho-Ser206) rabbit pAb

Name: Smad1 (phospho-Ser206) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES13078

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;IHC

Cellular localization

Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

4086

Human swiss prot no

Q15797

Immunogen

Synthesized phosho peptide around human Smad1 (Ser206)

Isotype

IgG

Observed band

52kD

Product weight

0.005kg

Reactivity

Human;Rat;Mouse;

Recommended dilutions

WB 1:500-2000;IHC-p 1:50-300

Source

Rabbit

Storage

-20°C/1 year

Background

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-med

Smad1 (phospho-Ser206) rabbit pAb

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