SMAD7 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES11276
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;ELISA
Cellular localization
Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
4092
Human swiss prot no
O15105
Immunogen
Synthesized peptide derived from part region of human protein
Isotype
IgG
Observed band
46kD
Product weight
0.005kg
Reactivity
Human;Mouse;Rat;Goat,Human
Recommended dilutions
WB 1:500-2000 ELISA 1:5000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
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Product Citations
Product Citations
More Info
More Info
SMAD7 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
