SMC1 (phospho Ser966) rabbit pAb

SMC1 (phospho Ser966) rabbit pAb

Vendor: ELK Biotechnology

SKU: ES7660

$148.00 USD
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Available in stock (100)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications
WB;IHC;IF;ELISA
Cellular localization
Nucleus . Chromosome . Chromosome, centromere, kinetochore . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral co
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
8243
Human swiss prot no
Q14683
Immunogen
The antiserum was produced against synthesized peptide derived from human SMC1 around the phosphorylation site of Ser966. AA range:932-981
Isotype
IgG
Observed band
160kD
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Recommended dilutions
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
SMC1 (phospho Ser966) rabbit pAb

SMC1 (phospho Ser966) rabbit pAb

$148.00 USD