Sovleplenib

Vendor: Abmole

Type: Molecular

SKU: M49931

$632.50 USD
Shipping calculated at checkout.

Documents

Coa

Available in stock (500)

  • Customs clearance fees may apply
  • Worldwide shipping available.
For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Sovalleplenib is a potent, orally active, selective Syk inhibitor with an IC50 of 25 nM.Sovalleplenib inhibits tyrosine kinase-dependent Fcγ receptor-mediated phagocytosis by macrophages, which in turn reduces phagocytotic destruction of platelets, as well as reduces production of antiplatelet antibodies by B-cells.Sovalleplenib has antitumor activity in immune thrombocytopenia (ITP).
Casnumber
1415792-84-5
Formula
C24H30N6O3S
Mw
482.60
Psmiles
CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NCC5CNCCO5
Purity
>99.0%
Solubility
DMSO 25 mg/mL
Target synonyms
HMPL-523
Sovleplenib

Sovleplenib

$632.50 USD