SQSTM1/p62 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES11994
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB; IF
Cellular localization
Cytoplasm, cytosol . Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body . Cytoplasm, myofibril, sarcomere . In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiqui
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
8878
Human swiss prot no
Q13501
Immunogen
Synthesized peptide derived from human SQSTM
Isotype
IgG
Product weight
0.005kg
Reactivity
Human; Mouse;Rat
Recommended dilutions
WB 1:500-2000; IF/ICC 1:100-500
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009],
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More Info
More Info
SQSTM1/p62 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

