Stat3 (Acetyl-Lys49) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES12927
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IHC;IF;WB
Cellular localization
Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
6774
Human swiss prot no
P40763
Immunogen
Synthesized peptide derived from human Stat3 (Acetyl-Lys49)
Isotype
IgG
Observed band
88kD
Product weight
0.005kg
Reactivity
Human; Mouse; Rat
Recommended dilutions
IHC-p 1:50-200, WB 1:500-2000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
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More Info
More Info
Stat3 (Acetyl-Lys49) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
