TAS0728

Vendor: Abmole

Type: Molecular

SKU: M10709

$379.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
TAS0728 is an effective, selective, oral, irreversible, covalently bound HER2 inhibitor covalently bound to the C805 site of HER2, inhibiting its activity.IC50 The value is 13 nM. TAS0728 to BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and HUMAN HER2 IC50 The values are 4.9, 8.5, 31, 65, 33, 25, 86, and 36 nM, respectively. TAS0728 simultaneously inhibits phosphorylation of HER2, HER3 and its downstream effector proteins. Has antitumor activity.
Casnumber
2088323-16-2
Formula
C26H32N8O3
Mw
504.58
Psmiles
CN(C)C(=O)CC1=CC=C(NC(=O)C2=N[N](C3CCCN(C3)C(=O)C=C)C4=NC=NC(=C24)N)C(=C1C)C
Purity
>99.0%
Solubility
DMSO ≥ 100 mg/mL
TAS0728

TAS0728

$379.50 USD