Thyroglobulin rabbit pAb

Name: Thyroglobulin rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES8743

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

IHC;IF;ELISA

Cellular localization

Secreted . Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:8626858, PubMed:11082042). .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

7038

Human swiss prot no

P01266

Immunogen

Synthetic peptide from human protein at AA range: 2511-2560

Isotype

IgG

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

IHC-p 1:50-200, ELISA 1:10000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009],

Thyroglobulin rabbit pAb

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