TL12-186

Vendor: Abmole

Type: Molecular

SKU: M29440

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$460.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
TL12-186

TL12-186

$460.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Bioactivity
TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM).
Casnumber
2250025-88-6
Formula
C44H51ClN10O9S
Mw
931.46
Psmiles
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O
Purity
≥99.0%
Solubility
DMSO 200 mg/mL (ultrasonic)
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