Trimetrexate

Vendor: Abmole

Type: Molecular

SKU: M30234

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$552.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Trimetrexate

Trimetrexate

$552.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Bioactivity
Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
Casnumber
52128-35-5
Formula
C19H23N5O3
Mw
369.42
Psmiles
CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC
Purity
≥98.0%
Solubility
DMSO ≥ 61.5 mg/mL
Target synonyms
CI-898
Technical documents

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