Vepdegestrant (ARV-471)

Vendor: Abmole

Type: Molecular

SKU: M21158

$736.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer.ARV-471 is a heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes.ARV-471 causes ubiquitination and subsequent degradation of the estrogen receptor via the proteasome.ARV-471 potently degrades ER-positive The ER in breast cancer cell lines is potently degraded by ARV-471 with a DC50 value of approximately 2 nM.
Casnumber
2229711-68-4
Formula
C45H49N5O4
Mw
723.9
Psmiles
C1CC2=C(C=CC(=C2)O)C(C1C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CC5)CN6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8)C9CCC(=O)NC9=O
Purity
>99%
Solubility
DMSO 90 mg/mL
Target synonyms
ARV471; PF-07850327
Vepdegestrant (ARV-471)

Vepdegestrant (ARV-471)

$736.00 USD