Voacangine

Vendor: Abmole

Type: Molecular

SKU: M30211

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$1,012.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Voacangine

Voacangine

$1,012.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Bioactivity
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana.
Casnumber
510-22-5
Formula
C22H28N2O3
Mw
368.47
Psmiles
CCC1CC2CC3(C1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC)C(=O)OC
Purity
≥98.0%
Technical documents

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