WRN rabbit pAb
Vendor: ELK Biotechnology
SKU: ES20223
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB; ELISA
Cellular localization
Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
7486
Human swiss prot no
Q14191
Immunogen
Synthesized peptide derived from human WRN AA range: 1080-1160
Isotype
IgG
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Recommended dilutions
WB 1:1000-2000 ELISA 1:5000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
Werner syndrome RecQ like helicase(WRN) Homo sapiens This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008],
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Product Citations
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More Info
More Info
WRN rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
