YKL-5-124

Vendor: Abmole

Type: Molecular

SKU: M10734

$483.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
YKL-5-124 is a potent, selective, irreversible COVALENT inhibitor of CDK7 and CDK7/Mat1/CycH IC50 53.5 nM and 9.7 nM, respectively. YKL-5-124 is more than 100 times more selective to CDK7 than CDK9 and CDK2 and is inactive to CDK12 and CDK13. YKL-5-124 induces intense cell cycle arrest and inhibits E2F-driven gene expression with little effect on RNA polymerase II phosphorylation status.
Casnumber
1957203-01-8
Formula
C28H33N7O3
Mw
515.61
Psmiles
CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC(=O)C3=CC=C(NC(=O)C=C)C=C3)C1(C)C)C4=CC=CC=C4
Purity
>98%
Solubility
DMSO ≥ 60 mg/mL
YKL-5-124

YKL-5-124

$483.00 USD