ZX-29

Vendor: Abmole

Type: Molecular

SKU: M29459

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$517.50 USD
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For research use only — not intended for clinical or diagnostic purposes.
ZX-29

ZX-29

$517.50 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Bioactivity
ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.
Casnumber
2254805-62-2
Formula
C23H28ClN7O3S
Mw
518.03
Psmiles
COC1=C(NC2=NC=C(Cl)C(=N2)NC3=C(N[S;v6](C)(=O)=O)C=CC=C3)C=CC(=C1)N4CCN(C)CC4
Purity
≥99.0%
Solubility
DMSO 50 mg/mL (ultrasonic and warming and heat to 60°C)
Technical documents

Documents

Coa

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